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This medication is used to help relieve severe ongoing pain (such as due to cancer). Oxycodone belongs to a class of drugs known as opioid analgesics. It works in the brain to change how your body feels and responds to pain.

The higher strengths of this drug (more than 40 milligrams per tablet) should be used only if you have been regularly taking moderate to large amounts of opioid pain medication. These strengths may cause overdose (even death) if taken by a person who has not been regularly taking opioids.

Do not use the extended-release form of oxycodone to relieve pain that is mild or that will go away in a few days. This medication is not for occasional (“as needed”) use.

Description

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summary
Oxycodone is an opioid used in the management of moderate to severe pain.
Brand Names
Endocet, Endodan Reformulated May 2009, Nalocet, Oxaydo, Oxy.IR, Oxycontin, Oxyneo, Percocet, Prolate, Rivacocet, Roxicet, Roxicodone, Targin, Targiniq, Xolox, Xtampza
Generic Name
Oxycodone
DrugBank Accession Number
DB00497
Background
Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917.3 It is currently indicated as an immediate release product for moderate to severe pain and as an extended-release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.Label The first oxycodone containing product, Percodan, was approved by the FDA on April 12, 1950.5
Type
Small Molecule
Groups
Approved, Illicit, Investigational
Structure
Thumb
Weight
Average: 315.3636
Monoisotopic: 315.147058165
Chemical Formula
C18H21NO4
Synonyms
  • Dihydrohydroxycodeinone
  • Dihydroxycodeinone
  • Oxicodona
  • Oxycodone
  • Oxycodonum
External IDs

  • IDS-NO-002
  • N02AA05
  • NSC-19043
  • PF-00345439
  • PTI-821

PHARMACOLOGY

Indication
Oxycodone is indicated for the treatment of moderate to severe pain.There is also an extended-release formulation indicated for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period

Pharmacology

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Associated Conditions

  • Severe Pain
  • Severe, Chronic Pain
  • Acute, moderate Pain
  • Chronic, moderate Pain
  • Severe Pain, Acute
Contraindications & Blackbox Warnings
Contraindications

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Pharmacodynamics
Oxycodone acts directly on a number of tissues not related to its analgesic effect. These tissues include the respiratory centre in the brain stem, the cough centre in the medulla, muscles of the pupils, gastrointestinal tract, cardiovascular system, endocrine system, and immune system.Oxycodone’s effect on the respiratory centre is dose dependant respiratory depression. The action on the cough centre is suppression of the cough reflex.Pupils become miopic or decrease in size, peristalsis of the gastrointestinal tract slows, and muscle tone in the colon may increase causing constipation.In the cardiovascular system histamine may be released leading to pruritis, red eyes, flushing, sweating, and decreased blood pressure.Endocrine effects may include increased prolactin, decreased cortisol, and decreased testosterone. It is not yet known if the effects of opioids on the immune system are clinically significant.
Mechanism of action
The full mechanism of oxycodone is not known,Under conditions of inflammation or hyperalgesia, opioid receptors in the heart, lungs, liver, gastrointestinal tract, and reproductive system are upregulated and transported to nerve terminals.Oxycodone and its active metabolites, noroxycodone, oxymorphone, and noroxymorphone are opioid agonists. These compounds passively diffuse across the blood brain barrier or may be actively transported across by an unknown mechanism. Oxycodone and its active metabolites can selectively bind to the mu opioid receptor, but also the kappa and delta opioid receptors in the central nervous system and periphery, and induce a G protein coupled receptor signalling pathway. Activation of mu opioid receptors inhibits N-type voltage operated calcium channels, inhibiting responses to pain.

TARGET ACTIONS ORGANISM
AMu-type opioid receptor
agonist
Humans
AKappa-type opioid receptor
agonist
Humans
ADelta-type opioid receptor
agonist
Humans
Absorption
Oxycodone has an oral bioavailability of 60% to 87% that is unaffected by food.

The area under the curve is 135ng/mL*hr, maximum plasma concentration is 11.5ng/mL, and time to maximum concentration is 5.11hr in patients given a 10mg oral immediate release dose of oxycodone.

Volume of distribution
2.6L/kg.
Protein binding
45%.Oxycodone is primarily bound to serum albumin and to a lesser degree alpha1-acid glycoprotein.
Metabolism
Oxycodone’s hepatic metabolism is extensive and completed by 4 main reactions. CYP3A4 and 3A5 perform N-demethylation, CYP2D6 performs O-demethylation, unknown enzymes perform 6-keto-reduction, and unknown enzymes perform conjugation.

Oxycodone is metabolized by CYP3A4 and CYP3A5 to noroxycodone and then by CYP2D6 to noroxymorphone.Noroxycodone and noroxymorphone are the primary circulating metabolites. Noroxycodone can also be 6-keto-reduced to alpha or beta noroxycodol.

Oxycodone can be metabolized by CYP2D6 to oxymorphone and then by CYP3A4 to noroxymorphone.Oxymorphone can also be 6-keto-reduced to alpha or beta oxymorphol.

Oxycodone can also be 6-keto-reduced to alpha and beta oxycodol.

The active metabolites noroxycodone, oxymorphone, and noroxymorphone can all be conjugated before elimination.

 

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